This web page was produced as an assignment for an undergraduate course at Davidson College.

Crigler-Najjar Syndrome

Crigler-Najjar Syndrome a disease caused by a single base deletion in the gene for a liver enzyme that metabolizes bilirubin (1). Therefore, the body fails to break down bilirubin (a yellow pigment), which accumulates to toxic levels (1). Therefore, the patient becomes juandiced and must spend up to 16 hours a day under blue lights to break down the pigment. Crigler-Najjar disease is fatal if untreated, and liver transplant is the only known cure (1).

For more information on Crigler-Najjar Syndrome, follow these links:

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