Enolase Genbank Search Results
 

Glycolysis is an anaerobic process by which glucose is broken down into two molecules of pyruvic acid, and it involves two phases: the energy-investment phase and the energy-yielding phase. The cell spends ATP in the energy-investment phase, while ATP is produced via phosphorylation in the energy-yielding phase. Specific enzymes are involved in the catbolic pathway of glycolysis-each one is substrate-specific and produces an intermediate product in the conversion of glucose to pyruvate. Enolase is one of the enzymes involved in the energy-yielding phase of glycolysis. The function of enolase is to convert the compound 2-Phosphoglycerate to Phosphoenolpyruvate. Enolase performs this function by extracting a water molecule from 2-Phosphoglycerate to catalyze the formation of a double bond. Phosphoenolpyruvate is the product that results from this enolase-driven reaction.

Click here to view the rasmol image of Enolase complexed with Mg²⁺ in Saccharomyces cerevisiae.

Because the glycolysis catabolic pathway is carried out in a wide range of organisms, the enolase enzyme is produced by and functions in a variety of different organisms. Enolase sequence similarities and/or differences between two or more organisms can be analyzed using Genbank. Below are Genbank entries for enolase amino acid and nucleotide sequences in five different organisms.