Gene Networks Database

Heliocidaris erythrogramma Genes in Development: Wnt genes



HeWnt-5 is a member of the Wnt gene family, one of the principal families of secreted signaling molecules that orchestrate the development of both invertebrate and vertebrete embryos.
Southern blot analysis demonstrated that HeWnt-5 is a single copy gene (Ferkowicz et al., 1998).


HeWnt-5 is a cell signaling protein.
All idetified sea urchin Wnt sequences contain nine absolutely conserved cysteine residues and a potential N-linked glycosylation sequence (Ferkowicz et al., 1998).
GenBank: 3808208

Subcellular location

Wnt proteins are secreted and do not diffuse more than a few cell diametres from Wnt-expressing cells (Nusse and Varmus, 1992, Siegfried and Perrimon, 1994).

Expression Pattern

The HeWnt-5 transcripts are detected at all stages of development after the early blastula stage. HeWnt-5 transcript levels rise through the late gastrula stage and then exhibit a second phase of increased expression during later stages when the adult rudiment is forming in this species (Ferkowicz et al., 1998).

mRNA level

Temporal accumulation

Method 1: RNase protection assay
Reference: Ferkowicz et al., 1998
StageUnfertilized egg 16 cells Late cleavage Early blastula Mesenchyme blastula Early gastrula Late gastrula 36-h early larva 53-h midlarva 70-h late larva 94-h metamorphosing juvenile
+ +
+ +
+ +
+ +
+ +



Regulatory Regions

Regulatory Connections

Upstream Genes


Downstream Genes

Evolutionary Homologues



[Previous] UrchiNet[Up] Search the GeNet
Comments are welcome to Sveta Surkova
Copyright © 1997 GeNet Team