Gene Networks Database
erythrogramma Genes in Development: Wnt genes
HeWnt-5 is a member of the Wnt gene family, one of the principal families of secreted
signaling molecules that orchestrate the development of both
invertebrate and vertebrete embryos.
Southern blot analysis demonstrated that HeWnt-5 is a single copy gene (Ferkowicz et al., 1998).
HeWnt-5 is a cell signaling protein.
All idetified sea urchin Wnt sequences contain nine absolutely
conserved cysteine residues and a potential N-linked glycosylation sequence (Ferkowicz et al., 1998).
Wnt proteins are secreted and do not diffuse more than a few cell diametres from Wnt-expressing cells (Nusse and Varmus, 1992, Siegfried and Perrimon, 1994).
The HeWnt-5 transcripts are detected at all stages of development
after the early blastula stage. HeWnt-5 transcript levels rise through the
late gastrula stage and then exhibit a second phase of increased
expression during later stages when the adult rudiment is forming in
this species (Ferkowicz et al., 1998).
Method 1: RNase protection assay
Reference: Ferkowicz et al., 1998
||36-h early larva
||70-h late larva
||94-h metamorphosing juvenile
- HeWnt-4 H. erythrogramma
- SpWnt-1 S. purpuratus
- SpWnt-4 S. purpuratus
- SpWnt-5 S. purpuratus
- HtWnt-5 H. tuberculata
- Wnt genes Mus musculus
- Wnt genes Xenopus laevis
- Wnt genes Evasterias troschelii
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Comments are welcome to Sveta Surkova
Copyright © 1997 GeNet Team