Immunology - Spring 2006

Dr. A. Malcolm Campbell

Dana 221 phone: x2692 email: macampbell

office hours: Mon. 2:00-3:30 and Tues. 10:30-noon


Reading Schedule

Methods Links

 Day

 Sections

  Notes, Comments, Links

 Jan. 9  Introduction and Entrance Exam  Immunology Syllabus
 Jan. 11  1.1 - 1.14

HHH - cell types
HHH- bone marrow
HHH- thymus
HHH- lymph node
HHH- spleen
Lymphocytes on the move - QT movie
Endocytosis by lymphocytes - QT movie

Somatic Recombination - Flash Animation
B Cell Development - Flash animation
B cell Selection - Flash Animation

JMOL view of Antibody
Fab fragment with bound antigen (lysozyme)

 Jan. 13  1.14 - 2.9

macrophage eating a pathogen

skim complement sections

Complement Cascade - by Jason Dyer
Alzheimer's, and Complement
TI B cell activation (also note complement receptors)

NK cell receptor binding MCH I

 Jan. 16
MLK Day

Campus-wide Activities

 Jan. 18  2.9 - 2.29

Cytokines:
- IFN-γ by Dax Allred '00; and Meredith Gramer '00
- IFN-β by Will White '00
- Lymphotoxin by Brenda Bondesen '00
- TNF - α by Rachel Wolf '00
- IL- 7 by Melanie Majure '00
- IL- 10 by Stacey Spolnik '01
- IL - 12 by Brent Wilson '00
- IL-2 γc Receptor

Chemokines:
Chemokine Families
Chemokines in Homing
Lymphocytes on the move - QT movie
Tissue Distribution of Chemokines

 Jan. 20  3.1 - 3.9 JMOL view of Antibody
Fab fragment with bound antigen (lysozyme)
antibody avidity (QT movie)
 Jan. 23  3.10 - 3.19 Jmol of MHCI (select Class I MHC)
Jmol of MHCII (select Class II MHC)
Murine T-Cell Receptor
Human TCR + HLA-A2 + HTLV-1 Peptide
CD8 (N-Terminal 114 Residues)
CD4 (D1D2 Fragment)
CD4 (D1-D4 and dimerized)
Complex Of The Human MHCI HLA-A2 & CD8
 Jan. 25  4.1 - 4.10

Somatic Recombination - Flash Animation
Somatic Hypermutation Mechanism
JMOL view of DNA-binding protein
HHH- bone marrow

 Jan. 27  4.11 - 4.21

Murine T-Cell Receptor
Human TCR + HLA-A2 + HTLV-1 Peptide
Thymus Histology (site of TCR gene recombination)
JMOL view of Antibody
antibody avidity (QT movie)

 Jan. 30
Clinical Day #1

(End of First Exam Material)
Case studies presented in class for your analysis/diagnosis.

 Feb. 1

Review Session
First Exam Distributed

Quiz Questions (photo only)
Clinical Case #1
Chapters 1 - 4 + Clinical Day

 Feb. 3  
First Exam Due

WWWorkshop

Web Standards for this course

Web Resources

 

 Feb. 6  5.1 - 5.8 Loading peptide in MHCI - Flash Animation
Loading peptide in MHCII - Flash Animation
Endocytosis by lymphocytes - QT movie
 Feb. 8  5.9 - 5.18

Human MHCIi HLA-Dr1 & Bacterial Superantigen Seb
TCR β Chain+ Sec3 Superantigen
Staphylococcal Enterotoxin Toxic Shock Syndrome Toxin-1
Staphylococcal Enterotoxin C2

MHC Haplotype Mapping

HLA-G - by Kelly Carter '00

 Feb. 10  6.1 - 6.16

TI B cell activation - Flash animation
IP3 signal transduction - Flash animation
Lck - written by Emily Lampp '00
MAPK pathway - Flash animation (by Dr. Vic Lemas)
JAK3
- written by Charles Haines '00
NFAT
- written by Tim Deeb '00
NFAT structure - Chime image shown with DNA

Quick Lesson on Apoptosis induced DNA fragments

 Feb. 13  6.17 - 6.22

NFkB JMOL image
IP3 signal cascade - Flash animation
TI B cell activation - Flash animation
Lck - written by Emily Lampp '00
MAPK pathway - Flash animation (by Dr. Vic Lemas)
Common g chain and JAK3 - by Charles Haines '00
Apoptosis

Knockout Mouse method
loxP + Cre recombination

 Feb. 15  7.1 - 7.16

HHH - cell types
HHH- bone marrow
HHH- thymus

B Cell Development - Flash animation
T Cell Development
- Flash animation (by Dr. Vic Lemas)
Somatic Recombination - Flash Animation (reminder)
NFkB JMOL image

 Feb. 17  7.17 - 7.25 B cell Selection - Flash Animation
T Cell Selection- Flash animation (by Dr. Vic Lemas)
 Feb. 20  7.26 - 7.35

HHH- lymph node
HHH- spleen

Karyotype of translocation - see Philadelphia Chromosome
OMIM information about bcl-2

(End Second Exam Material)

 Feb. 22
Clinical Day #2

Review Session
Second Exam Distributed

Chapters 5 - 7


 Feb. 24
Second Exam Due
no class
 thru 3/5

Spring Break!

Wear Sunscreen!

 Mar. 6  8.1 - 8.14

Thymus Histology
T Cell Selection
- Flash animation (by Dr. Vic Lemas)

Tc killing its target - QT Movie
Human TCR + HLA-A2 + HTLV-1 Peptide
Complex Of The Human MHCI HLA-A2 & CD8

 Mar. 8  8.15 - 8.25 Tc killing its target - QT Movie
Exocytosis Figure

Human TCR + HLA-A2 + HTLV-1 Peptide
Complex Of The Human MHCI HLA-A2 & CD8
 Mar. 10  8.26 - 8.29

Macrophage eating a pathogen

Apoptosis Pathway
Apoptosis cleavage of DNA
Apoptosis web Resources

 Mar. 13  9.1 - 9.11

B cell Selection - Flash Animation
Somatic Recombination - Flash Animation
HHH- lymph node
HHH- spleen
TI B cell activation - Flash animation

 Mar. 15  9.12 - 9.18 Complement Cascade - by Jason Dyer
Chime view of Antibody
Fab fragment with bound antigen (lysozyme)
antibody avidity (QT movie)
 Mar. 17  9.19 - 9.23

Eosinophils - HHH images
Histamine - by David Lamar '01
Oxidative Burst
IFN-β
- by Will White '00

Home Page on YFIP Due

 Mar. 20  10.1 - 10.12 HHH - Hyperlinked Human Histology
 Mar. 22  10.13 - 10.26

(End Third Exam Material)

 Mar. 24
Clinical Day #3
 
 Mar. 27
Review Session
Third Exam Distributed
Chapters 8 - 10
 Mar. 29
Third Exam Due
Web & "Term Paper" Help
 Mar. 31
No class
Out of town presentation
 Apr. 3  11.1 - 11.5

Plasmodium Images - by CDC
Animations of infection by Brett Finlay and HHMI

Bacteria
Bacterial Pathogens Triggers Endocytosis
- EM image
Animations of infection by Brett Finlay and HHMI
(click on Intracellular Infection by Salmonella in right hand column of links)

Listeria - symptoms and treatment

Salmonella enducing apoptosis
Salmonella and "organic foods"
Salmonella Fact Sheet

Helminths
Ascaris lumbricoides
- from CDC web site on parasites and diagnosis
Hookworm - from CDC web site on parasites and diagnosis

Protozoan
Leishmania - from CDC web site on parasites and diagnosis
Leishmania - Clinical
Leishmania - Immunity
Leishmania - Evading Destruction
Leishmania - Treatment

Viruses
HIV binding chemokine receptors - Flash animation by Hoffmann-La Roche

 Apr. 5  11.6 - 11.18

SCID1
SCIDX1

 Apr. 7  11.19 - 11.30

Life cycle of HIV (provided by Jim Sullivan of Cells Alive!)
Life cycle of HIV (Roche site, with drug interactions)
HIV Drug Resistance (by
WHO stats on AIDS
CD4 (D1D2 Fragment)
CD4 (D1-D4 and dimerized)

 Apr. 10  12.1 - 12.9

Eosinophils - HHH images
Histamine - by David Lamar '01

Size of mite poop

Aspirin (Jmol)
Cox1 (Jmol)
Cox1 acetylated(Jmol)

 Apr. 12  12.10 - 12.18

TI B cell activation - Flash animation
HHH - Germinal Center

 Apr. 14  13.1 - 13.15

Autoimmune Diseases:

 Apr. 17

 Easter Break

Get ready for the final sprint to graduation.....
 Apr. 19

 13.16 - 13.30

HLA-G - by Kelly Carter '00

MHC Haplotype Mapping

Jmol of MHCI (select Class I MHC)
Jmol of MHCII (select Class II MHC)
Murine T-Cell Receptor

 Apr. 21  13.31 - 13.39  
 Apr. 24  14.1 - 14.17

Hyperlinked Human Histology
Images of Tumors
Tc killing its target - QT Movie

 Apr. 26  14.18 - 14.30

Gene Gun for DNA vaccines
E. coli and Salmonella binding host cells
Chemokines to Block HIV Infections?

Liposomes for delivery of antigens?

Immune Related Disease/Codition Web Page Due

 April 28

Chapter 15

Course Evaluations

 Evolution of the Immune System

 Help me improve my teaching.

 May 1
Clinical Day #4
&
Slide Show

 Eye Movement Problems
(End Fourth Exam Material)

 Fellowships For You

 May 3
Review Session
Final Exam Distributed

Focus on Chapters 11- 15

 May 8

Final Exam @ noon

 All Exams Due for All Students!


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© Copyright 2006 Department of Biology, Davidson College, Davidson, NC 28035
Send comments, questions, and suggestions to: macampbell@davidson.edu