History of the Poison Dart Frog

photo compliments of 
Dr. Shin Sugiyama

Introduction

Toxin

Cellular 
Mechanism

Medicinal
Applications

Legends 
and Folklore

References

                                                             Map provided compliments of http://www.cia.gov/cia/publications/factbook/geos/ec.html
 

 
     Epipedobates tricolor is a type of poison dart frog that inhabits the rainforests of Ecuador.  Native hunters throughout South America have long been using the poisonous substances secreted by these tiny frogs to tip their arrows.  The first account of this practice, written in the English language, was recorded by a British Naval officer - Captain Charles Stuart Cochrane - following his exploration of Columbia.  His description detailed the methods used in the retrieval of the poison from the frogs as well as the process through which the poison arrows were created.  After observing the Chocó Indians from the mountain region of Columbia, Cochrane concluded that any stress applied to the frogs caused them to secrete the poisonous substance.  Once the frogs were sufficiently agitated they secreted a white, frothy substance that was collected and applied to the tips of arrows.  If applied in the appropriate manner, these arrows could maintain their efficacy for almost a year.  Native hunters claimed that the secretions from one frog could tip as many as fifty arrows. (Bainbridge, 1989)  The art of hunting by this method is now a dying one among the Chocó people of Columbia.  Since the introduction of firearms to the native population, only a few members of the Chocó people continue to engage in the risky practice of making poison arrows. (Moffet, 1995)  Although the ancient hunters of South America have long since lost interest in the frogs’ poisonous secretions, present day scientists have become quite interested in the possible medicinal benefits of the compounds secreted by these deadly frogs.  John Daly, a researcher for the National Institute of Health, has pioneered the investigation. 
 
  

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This website was created for a biology course entitled "From Venoms and Toxins to Drugs" at  College in Davidson, North Carolina.  All questions and/or comments should be directed to Amy Johnston.