Immunology - Spring 2000

Dr. A. Malcolm Campbell

Dana 221 phone: x2692 email: macampbell

office hours: M, 2-3:30 and Tues. 10 - 11:30 plus open door policy


Tentative Weekly Schedule

 Week

 Sections

  Notes or Comments

 Jan. 19 - 21    
 W  Introduction and Entrance Exam  Immunology Main Page
 F  1.1 - 1.11 HHH - cell types
HHH- bone marrow
HHH- thymus
HHH- lymph node
HHH- spleen
macrophage eating a pathogen
Chime view of Antibody
Fab fragment with bound antigen (lysozyme)

 Jan. 24 - 28    
 M  1.12 - 2.13 Tc killing infected cell - QT movie
ELISA method - QT movie
Antibody avidity - QT movie
Immunofluorescence methodology
Western Blot Figure image only

 W  2.14 - 2.27 FACS machine
RT-PCR - Flash animiation
loxP paper (restricted access)

 F  3.1 - 3.15 Chime view of Antibody
Fab fragment with bound antigen (lysozyme)
Somatic Recombination - Flash Animation
Chime view of dsDNA (for 12/23 rule)
Chime view of DNA-binding protein

 Jan. 31 - Feb. 4  
 M  3.16 - 3.24 Somatic Recombination - Flash Animation
Chime view of DNA-binding protein

 W  4.1 - 4.14 Chime of MHCI (select Class I MHC)
Chime of MHCII (select Class II MHC)
Loading peptide in MHCI - Flash Animation
Loading peptide in MHCII - Flash Animation
 F  4.15 - 4.22 Chime of MHCI (select Class I MHC)
Chime of MHCII (select Class II MHC)
Somatic Recombination - Flash Animation
HLA-G - written by Kelly Carter '00

 Feb. 7 - 11    
 M  4.23 - 4.30 Murine T-Cell Receptor
Human TCR + HLA-A2 + HTLV-1 Peptide
Human MHCIi HLA-Dr1 & Bacterial Superantigen Seb
TCR b Chain+ Sec3 Superantigen
Staphylococcal Enterotoxin Toxic Shock Syndrome Toxin-1
Staphylococcal Enterotoxin C2
CD8 (N-Terminal 114 Residues)
CD4 (D1D2 Fragment)
CD4 (D1-D4 and dimerized)
Complex Of The Human MHCI HLA-A2 & CD8
Thymus Histology (site of TCR gene recombination)

 W  Clinical Day #1 (End of First Exam Material)
 F  Review Session and First Exam Distributed  
 Feb. 14 - 18    
 M  First Exam Due  WWW workshop
Web Standards for this course

How to create web pages
A template for your use
How to find a Chime File of YFIP
How to embed a Chime file in your web page
How to load your pages onto the BioServer
How to create relative links
How to make Greek letters in html

 W  5.1 - 5.10   (Begin Second Exam Material)
TI B cell activation - Flash animation
IP3 signal transduction - Flash animation
Lck - written by Emily Lampp '00
MAPK pathway - Flash animation (by Dr. Vic Lemas)

 F  5.11 - 5.20 IP3 signal transduction - Flash animation
NFAT - written by Tim Deeb '00
NFAT structure - Chime image shown with DNA
MAPK pathway - Flash animation (by Dr. Vic Lemas)
JAK3 - written by Charles Haines '00
Quick Lesson on Apoptosis induced DNA fragments

 Feb. 21 - 25    
 M  6.1 - 6.6 B Cell Development - Flash animation

 W  6.7 - 6.12 HHH - cell types
HHH of spleen

HHH of lymph node
B cell Selection - Flash Animation

 F  6.13 - 6.16 HHH of spleen
HHH of lymph node
HHH- bone marrow
Karyotype of translocation - see Philadelphia Chromosome
Chromosomal information about bcl-2

 Feb. 28 - Mar. 3    
 M  7.1 - 7.5 HHH- thymus
T Cell Selection- Flash animation (by Dr. Vic Lemas)

 W  7.6 - 7.11 HHH- thymus
Somatic Recombination - Flash Animation
T Cell Selection- Flash animation (by Dr. Vic Lemas)

 F  7.12 - 7.21 (End of Second Exam Material)

HHH- thymus
T Cell Selection- Flash animation (by Dr. Vic Lemas)


Home Page on YFIP Due by noon

 March 6 - 10    
 M W F

 Spring Break!!


 March 13 - 17    
 M  8.1 - 8.13

(Begin Third Exam Material)
HHH - Hyperlinked Human Histology
Signal Transduction (Review Animations Below)


 W  Clinical Day #2 Common g chain and JAK3 - by Charles Haines '00
 F  Review Session Second Exam Distributed

 March 20 - 24    
 M  Second Exam Due Plus Web & Term Paper Help

 W  8.14 - 8.22 Apoptosis Pathway
Apoptosis cleavage of DNA
Apoptosis web Resources
Exocytosis Figure
Tc killing its target - QT Movie
IP3 Pathway

 F  8.23 - 8.28

Cytokines:
- IFN-g by Dax Allred '00; and Meredith Gramer '00
- IFN-b by Will White '00
- Lymphotoxin by Brenda Bondesen '00
- TNF - a by Rachel Wolf '00
- IL- 7 by Melanie Majure '00
- IL- 10 by Stacey Spolnik '01
- IL - 12 by Brent Wilson '00

Chemokine Families

Leishmania - Clinical
Leishmania - Immunity
Leishmania - Evading Destruction
Leishmania - Treatment

Interesting Approach to Learing about Listeria
Listeria - symptoms and treatment


 March 27 - 31  
 F 9.1 - 9.10 TI B cell activation - Flash animation
HHH - Germinal Center

 W  9.11 - 9.21

Eosinophils - HHH images
Histamine - by David Lamar '01

Bacteria
Bacterial Pathogens Triggers Endocytosis
- EM image
Animations of infection - by Brett Finlay and HHMI

Salmonella enducing apoptosis
Salmonella living inside macrophages
Salmonella and "organic foods"
Salmonella Fact Sheet

Helminths
Ascaris lumbricoides
- from CDC web site on parasites and diagnosis
Hookworm - from CDC web site on parasites and diagnosis

Protozoan
Leishmania
- from CDC web site on parasites and diagnosis


 F  9.22 - 9.31 (skim complement) plus 10.1 - 10.5 Complement Cascade - by Jason Dyer
TI B cell activation (note complement receptors)
Alzheimer's, Down's Syndrome and Complement

 April 3 - 7  
 M  10.6 - 10.15 Oxidative Burst
IFN-b
- by Will White '00
HIV binding chemokine receptors - Flash animation by Hoffmann-La Roche

 W  10.16 - 10.29 Hyperlinked Human Histology
Chemokines in Homing
Tissue Distribution of Chemokines
(End of Third Exam Material)

 F  Review Session  Third Exam Distributed
 April 10 - 14  
 M  Third Exam Due  More help with WWW and Papers
 W  11.1 - 11.13 Plasmodium Images - by CDC
Animations of infection - by Brett Finlay and HHMI
TI activation of B cell

B Cell Development
Complement Cascade
MHC II peptide loading
MHC I peptide loading
IL-2 gc Receptor

 F  11.14 - 11.25 WHO stats on AIDS (1997)
HIV binding chemokine receptors
- Flash animation by Hoffmann-La Roche

 April 17 - 21  
 M Clinical Day #3 Eye Movement Problems

 W  12.1 - 12.9 HHH - eosinophils
histamine - by David Lamar '01

 F  12.10 - 12.18 Penicillin G structure (b-lactam ring with 3C and 1N)
ELISA method - QT movie
Paper Must be Posted by Noon
 April 24 - 28  
 M

 Easter Break


 W  13.1 - 13.13

Chime of MHCII (select Class II MHC)
Loading peptide in MHCII - Flash Animation

Autoimmune Diseases: restricted - campus only


 F  13.14 - 13.29 HLA-G - by Kelly Carter '00

 May 1 - 5    
 M  14.1 - 14.10

Information about NFAT - by Tim Deeb '00

NF-AT structure - Chime image shown with DNA


 W  14.11 - 14.15 plus news stories Images of Tumors

 F  14.16 - 14.28 Gene Gun for DNA vaccines
Chemokines to Block HIV Infections?

 May 8 - 10    
 M Clinical Day #4 Eye Movement Problems
(End of Final Exam Material)

 W  Slide Show + Review Session Fourth Exam Distributed

 F  Final Exam Due 5 pm Grading starts promptly at 5:01 pm!



© Copyright 2002 Department of Biology, Davidson College, Davidson, NC 28036
Send comments, questions, and suggestions to: macampbell@davidson.edu